If you are trying to move out the use statements from the code into the Apache config, I don't think it makes much sense. A goal of mod_perl is to load the required modules at Apache startup, which will improve performance and memory use. The subsequent use at the actual Perl script costs very little -- it only imports the module's functions into the script's namespace.

Besides, if you want to erase those use statements from the actual scripts, it will be a maintenance nightmare should any of the scripts ever have to be moved.