Yes, Samtools is already compiled and works fine. Forgive me if you know this already, but Samtools is a separate collection of scripts. The Bio::DB::Sam, which i am trying to install provides an API to these functions. the installation instructions are:

perl Build.PL

./Build

./Build test

(sudo) ./Build install

I then run:

>Bio-SamTools-1.33 user$ perl Build.PL
This module requires samtools 0.1.10 or higher (samtools.sourceforge.n
+et).
Please enter the location of the bam.h and compiled libbam.a files: /U
+sers/user/Programs/samtools-0.1.17          

Found /Users/user/Programs/samtools-0.1.17/bam.h and /Users/user/Progr
+ams/samtools-0.1.17/libbam.a.
Set up build environment without MacOSX10.5 SDK (will build i386 binar
+ies)
Set up build environment without MacOSX10.5 SDK (will build i386 binar
+ies)
Created MYMETA.yml and MYMETA.json
Creating new 'Build' script for 'Bio-SamTools' version '1.33'
[download]

then:

> Bio-SamTools-1.33 user$ ./Build
Set up build environment without MacOSX10.5 SDK (will build i386 binar
+ies)
Set up build environment without MacOSX10.5 SDK (will build i386 binar
+ies)
Set up build environment without MacOSX10.5 SDK (will build i386 binar
+ies)
Building Bio-SamTools
[download]

then i run ./Build test and get the output detailed in the original post. thanks,