I find no problems with it. I even accidenty mailed fmogo@mninter.net. ;)

I guess it's a problem with your exchange server or you reaching it.

Update 2 By default Send.pm uses Mailer.pm which by default uses mail or sendmail to deliver your message. You might want to try explicitly specifying your smtp-server and thereby implicitely using Net::SMTP. You're not dependent on mail or sendmail being installed, which is I guess cause of the 270-error.

require Mail::Send;

$msg = new Mail::Send;
$msg->to('fmogo@mninter.net');
$msg->subject('Send Mail Test');
$msg->delete($header);
$fh = $msg->open('smtp', Server => "smtp.uu.nl") or die "Couldn't open
+ message: $!" ;
print $fh "Just testing the Mail::Send package";
$fh->close;
[download]

Perhaps this works.