You must be having problems with committing changes to the database. Rather than fiddling with Win32::ODBC, I would suggest using DBI and DBD::Oracle instead.

use strict;
use DBI;

my $db = DBI->connect( $dbasename, $user, $pword ) or die DBI->errstr;
my $ss = $db->prepare( 'update employee set remarks = ? where emp_no=?
+ and emp_join_year = 1001 ' ) or die $db->errstr;

while( <DATA> ) {
  chomp;
  my( $remark, $emp_no, $join_year ) = split "~~";
  $ss->execute( $remark, $emp_no, $join_year );
}
$ss->finish;
$db->disconnect;
__DATA__
Test now for Ryan~~295~~200102
Test later for grinder~~29008~~200005
[download]

DBI runs just fine on both Win32 and Unix systems, thus your code will be much more portable (maybe not a big concern) and your skill set will also be more portable. This is of a greater concern, because it means you can ask for more money at your next job!

NB: rough code sketch, no guarentees that it works as advertised.

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g r i n d e r