Of course we have not yet seen the formats of your input files, but I'd do something along the following lines:

use Modern::Perl;
use Regexp::Assemble;

# first we make one big regex.
my $ra = Regexp::Assemble->new;
$ra->add(<DATA>);
say $ra->as_string;    # to see how the regex looks
my $regexp = $ra->re;

open my $HOMEFILE, '<', '/home/file.csv';
open my $OUTPUT,   '>', '/tmp/file.report';
while (<$HOMEFILE>) {
    /$regexp/ and say $OUTPUT "Something in [$_] matched";
}

__DATA__
my.email@somewhere.com
your.postbox@anywhere.net
our.address@dropithere.org
me.andmyself@sendit.com
[download]

Of course you will need to add some dies to check all your files opened properly. or use autodie to save you the hassle.