I'm using it without any problems. I'm used to developing in a Visual Studio environment, however, as I also develop in VC++ and VB. Moving to the new .NET tools and platform was a relatively painless task (except for the politics involved in getting servers upgraded so that I could actually USE these cool new webservices), and the Visual Perl IDE was a welcome addition. It means that I can do 95% of all of my development in one common environment.
I'm also liking what I see from C# and the other .NET langs. I've only written two webservices so far, but I have a feling I'll be developing more of them in the future as the first two grow in popularity.
YMMV, some restrictions may apply.
C-.