No, changes to the directory entry that was used to open the file (incl renaming and deleting) would not result in that error.

Unix: Doing these things has no effect on the file, to which one can continue writing. It would not produce an error at all.

Windows: File handles opened by Perl don't even allow those operations to occur. (This is standard.)

In reply to Re^2: Bad file descriptor when trying to close file handle by ikegami
in thread Bad file descriptor when trying to close file handle by fireblood

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