hilitai, with the ideas generated by the other Monks, I was able to come up with this, which worked for me on Win7 strawberry 5.24.1 and linux perl 5.8.5.

#!/usr/bin/perl

use strict;
use warnings;
my $usemod;     # if you initialize `my $usemod = 0;`, then the BEGIN 
+block's assignment to $usemod is overridden, which you don't want
our $Registry;  # this will be overridden by Win32::TieRegistry's expo
+rt of $Registry if in Windows, but

BEGIN {
    local $\ = "\n";
    if( $^O eq 'MSWin32' ) {
        eval {
            require Win32::TieRegistry;
            Win32::TieRegistry->import( Delimiter => '/' );
            $usemod = 1;
        }
    }
}

if ($usemod) {
    my $IEKey = $Registry->{'HKEY_CURRENT_USER/Software/Microsoft/Inte
+rnet Explorer/Main/'};
    print "IEKey = '$IEKey'\n";
} else {
    print "None of that stuff here\n";
}
[download]

• my 5.8.5 linux perl didn't like the use if ... (edit: or, at least, the way I tried... with some debug, it may have eventually worked), so I went with Discipulus's BEGIN block idea to make that run first

• removing the = 0 on my $usemod; allowed the $usemod variable to update in the BEGIN block
• used Perlbotics' suggestion of ->import(), though I included your Delimiter => '/' argument to the import
• made $Registry a package variable using our, which then allowed the Win32::TieRegistry->import() to clobber it with the defined version from the module, while still allowing linux perl to compile the script

edit#2: added use warnings; per best practices

edit#3: added "perl" to "linux perl 5.8.5", so it wasn't implying that was the version of linux, but rather the version of perl

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