The wise monks have already replied to your answer,
1. Bulk insert is the fastest way to Insert large data.
2. Remove Indices before Inserting and later recreate the Indices.
3.perl DBI does not support Bulk Insert so you have to use the option provided by the Database (this is different for each database ..)

Also see if DBD::SqLite can be of help ,As per its documentation this is faster than mysql.

In reply to Re: Implementing a buffered read-and-insert algorithm by mkirank
in thread Implementing a buffered read-and-insert algorithm by radiantmatrix

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