Check your outgoing mail (smtp) port and smtp server information (Example: 192.125.1.45). In sendmail.pm, default port value given is 25 (change it if you always use a non-standard port). 
unshift @{$Mail::Sendmail::mailcfg{'smtp'}} , "192.125.1.45";

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In reply to Re: Mail::Sendmail - how to configure mail server? by cognizant
in thread Mail::Sendmail - how to configure mail server? by Anonymous Monk

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