It probably contains more than what you asked for, but you might find some useful tips in this node:

• On Interfaces and APIs (see especially "GUI Design Checklist" section)

GUI References Added Later

Tk:

• Tk (software) (wikipedia)
• Tk (CPAN)

• tie *STDOUT fails in Tkx by perlboy_emeritus (2024)
• Tk install failing by ckmate-king-2 (2024)
• Unable to install Tk module for Strawberry Perl by vinoth.ree (2023)
• Tk::Tree how to set color of entry after tree creation by EnzoXenon (2024) - choroba shows how to use Tk::Tree, Tk::HList and Tk::DItem
• Re: Unable to install Tk module for Strawberry Perl by KeighleHawk (2024) - installing Tk with Strawberry Perl v5.32.1 worked while v5.38.0 failed
• Tk in Strawberry on W10 by gsd4me (2024) - problems installing Tk with Strawberry Perl
• Re: Tk in Strawberry on W10 by gsd4me (2024) - installing Tk turning into a saga, just wants a simple life
• Tk Entry & Right Single Quote by cmv (2024) - dealing with ASCII single quote (') vs smart quotes aka Unicode Right Single Quote and Left Single Quote
• Interrupting a loop by merrymonk (2024) - Perl Tk button fails to respond, good response re Ctrl-C and Tk::after from choroba
• Tk module installation by cpan by vinoth.ree (2010)

• PerlTk using -configure across frames by colintu (Jul 2024)
• Tk Entry widget confusion by colintu (Jul 2024)
• Re^2: Reading into array with sscanf by colintu (Jul 2024) - code being used in a Tk widget
• Tags in TK Text widgets by colintu (Aug 2024) - I have a Text widget in which I need to mark 'invalid' characters by changing their colour

• Perl installation on Ubuntu and/or Mac OS by merrymonk (Aug 2024) - good ways to install Perl and Tk on Ubuntu or Mac OS for a non-programmer

• Perl Tk label references by thimes (2016)
• Problem installing Perl/Tk by thimes (2023)
• cpanm Tk build errors by thimes (2024)

• Tk::Canvas createGroup() Undocumented by kcott (2021) - looking at feasibility of using Tk::Canvas to generate simple, interactive maps for use with RPGs
• Creating X BitMap (XBM) images with directional gradients by kcott (2021) - project to create interactive maps for RPGs with Tk and Tk::Canvas (many replies over many years, replies mentioned at Mathematical References)
• Quick script to check data logger data by GrandFather (2021) - uses Math::FFT, Tk, Tk::Canvas ... etj response suggests PDL well suited to this problem

• Adventures in Debugging a Perl/Tk Game by liverpole (2008)
• Re: High Performance Game of Life by zentara (2017) - ideas for using Perl/Tk and Tk::Canvas in visualizing Conway's Game of Life
• Tk - Discipulus 15 puzzle by Discipulus (2017) - classic puzzle game dedicated to my 15th anniversary at PM

• Windows Tk issue Copy and Paste Russian keyboard by IB2017 (2017) - how to copy and paste (Ctrl+C and Ctrl+V) in Tk on a Russian keyboard? soonix solves via Control+Insert = Copy, Shift+Insert = Paste, Shift+Delete = Cut, see also Cut, copy, and paste (wikipedia)
• ... most of IB2017's 154 nodes are related to Tk, so there are plenty more waiting to be checked out :-)
• How to align the contents inside a ListboxSelect of Tk GUI by Evel (2017) - responses from kcott and Discipulus

• Tk install fails by elef (2024) - answered by syphilis and swl ... also with Re^3: Unable to install Tk module for Strawberry Perl (many replies from syphilis in Tk in Strawberry on W10)
• How to name a module providing a systray morbo controller by capfan (2024) - note BTW that capfan has a Perl/Tk web site

• Strange behavior of iteration while creating Perl/Tk widgets dynamically by Vasek (2021) - music program, how to produce a range of colours for each musical degree
• Binding AltGr + minus key (=asterisk) by Vasek (2024) - how to catch the simultaneous pressing of AltGr (or left Alt + Control) and any other character in a Tk application
• Tk TableMatrix highlighted cell color by Takamoto (2024)

• Changing state for gridded Entry? by cniggeler (2023)

• General advice desperately needed by twv (2015) - seeking advice installing Tk on Windows
• Unable to instal Tk by twv (2015) - ditto

• Perl/Tk code structure by elef (2012)
• Odd encoding problem in Tk app when packaged with pp by elef (2013)
• Auto-adjust row height to line wrap in Tk-Tablematrix by elef (2013)
• Perl/Tk and PAR::Packer on OS X by elef (2013)
• Query the height of Tk::Text widget with word wrap by elef (2013)
• Tk BrowseEntry with only the arrow button visible? by elef (2013)

• Using Tk inside a Perl exe by Garden Dwarf (2018) - perl program working fine, but when converting to an exe (using pp), it dies
• Tk multiple monitor problem by JohnRS (2012) - GUI project using Strawberry Perl 5.12.3 and pTk 804.03 on Windows, problem with DialogBox not positioning correctly in a multiple monitor environment

GNOME:

• GNOME (wikipedia) - a free and open-source desktop environment for Linux and other Unix-like operating systems
• GNOME Project (wikipedia)

GTK:

• GTK (wikipedia)
• Gtk2 (CPAN) - Perl interface to the 2.x series of the Gimp Toolkit library
• GIMP (wikipedia)

• Compiling Gtk+ stack on windows with strawberry perl by frazap (2016)
• How to printout a Gtk2::ComboBox by dabella12 (2019)
• GTK change background images by holandes777 (2020)
• GTK3 Treeview question by richardrosa (2023)
• Tk, Gtk or... by TheoPetersen (2001)
• Re: Playing around with yad and Perl by The_Dj (2024) - responding to harangzsolt33

Win32:

• Win32::GUI and threads issue by Garden Dwarf (2019)
• [SOLVED] Win32::GuiTest::SendMessage/AllocateVirtualMemory and TCHAR** by pryrt (2019)
• Win32::GUI ; Click and DoubleClick by The_Dj (2021)
• How to get Tooltips working in Win32::GUI::TreeView? by The_Dj (2022)
• How to name a module providing a systray morbo controller by capfan (2024)
• Object isn't fully affected by the Animate method in Win32::GUI module by anonymonk (2024)

Prima:

• Prima GUI TK by igoryonya (2019)
• GUI question: Prima: password input fields by docsnyder (2019)
• Help needed Using Prima GUI by SR (2007)

GUI Design:

• On Interfaces and APIs (see especially "GUI Design Checklist" section)
• Re^2: Tk in Strawberry on W10 by me (2024)
• GUI Design/Organization - Recommended Practices? by atcroft (2016)

On CPAN:

• Tk by Slaven Rezic - a graphical user interface toolkit for Perl
• Tk::Canvas by Slaven Rezic - create and manipulate Canvas widgets

• Prima by Dmitry Karasik - a Perl graphic toolkit
• Win32::SysTray (mentioned in this node) by Andreas Mahnke - create perl applications that are stored in the Windows system tray
• Win32::GUI (mentioned in Object isn't fully affected by the Animate method in Win32::GUI module)
• Win32::GuiTest (mentioned in [SOLVED] Win32::GuiTest::SendMessage/AllocateVirtualMemory and TCHAR**)

• Imager by tonyc - Perl extension for Generating 24 bit Images

Outside References:

• Trouble installing Tk module for perl using CPAN (SO) - 2020
• Graphical User Interface (GUI) Development in Perl (Perl Beginners Site)
• Prima: Cross-platform GUI toolkit written in Perl (Hacker News)
• Perl Prima GUI Toolkit (Reddit)

Books:

• Learning Perl/Tk (O'Reilly book by Nancy Walsh)
• Mastering Perl/Tk (O'Reilly book by Stephen Lidie & Nancy Walsh)

• Don't Make Me Think, Revisited book by Steve Krug (thanks Bod)

See Also

• Re^2: Organizational Culture (Part II): Meta Process (BioPerl/PDL/AI/Embedded/GPGPU/Data Science References)