If you want to the letters to be a secundary sort key, you can try this:

$ perl -e 'use strict;

> use warnings;
> use Data::Dumper;
>
> my @a = qw / E1180 D250 A1180 E855 E975 A130 A250 B1105 B1255 B2480 
+C1180 C1600 D1180 /;
>
> print "$_\n"
>         for map "$_->[0]$_->[1]",
>         sort { $a->[1] <=> $b->[1] || $a->[0] cmp $b->[0]}
>         map { /([A-Z]+)(\d+)/; [$1, $2]} @a;
> '
A130
A250
D250
E855
E975
B1105
A1180
C1180
D1180
E1180
B1255
C1600
B2480
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Notice that A250 and D250 are now sorted alphabetically on the initial letter. For a reverse alphabetical order on the letters, change the sort line to this:

sort { $a->[1] <=> $b->[1] || $b->[0] cmp $a->[0]}
[download]