This seems to work, though I'm sure there'll be prettier ways: 
perl -lne 's/(?<=.{188})(\d{8})(?=.{16})/$1 eq "00000000"?next:"200201
+01"/e && print' original.txt > new.txt

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In reply to Re: search and replace on a line by line basis by ishnid
in thread search and replace on a line by line basis by Anonymous Monk

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