I think you should be able to manipulate @ISA just like any other array, i.e. something like (untested): 

av_push( get_av("SomeClassName::ISA",1), newSVpv("SomeBaseClass",0) );

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In reply to Re: perlapi magic: setting ISA from C code by almut
in thread perlapi magic: setting ISA from C code by kingkongrevenge

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