I'm running the stock Perl 5.10.0 that came with Snow Leopard, and it's definitely running as a 64 bit app on my machine. For me, the version of Perl 5.10.0 that shipped with Snow Leopard worked okay with a fresh install of 64 bit MySQL and clean build of DBD::mysql

I wonder if you're seeing problems from multiple incompatible versions of Perl libs being installed or having a library path issue?

In reply to Re^3: MAC OS 10.6 upgrade breaks DBD:mysql by romkey
in thread dyld: lazy symbol binding failed (was MAC OS 10.6 upgrade breaks DBD:mysql) by finhagen

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