in PDF letters are placed by absolute positions. So replacing glyphs with different metrics will most probably result in broken
documents rendering.
You should consider exporting to a textfile and doing the replacement there. (see Parsing PDFs by text position?)
Or to run a little script on the pasted text.
E.g. with emacs you could run a hook on every insert, which could do the transformation.
Or maybe ... did you check if your pdf reader allows to run hooks on copies... ?
> and impossible to know what letters it should be.
I doubt this could you give us some examples?
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