perl -pi.bak -e 's/manulation/modification/' file.txt

Actually that will change the first (and supposedly unique) occurrence of 'manulation' in every line: indeed this makes sense, because the OP's request is sloppy to begin with. Anyway, he stresses that the substitution he wants must take place in a "particalur line" and mentions Tie::File, although to the effect of not wanting to use it. Thus I suspect he really wants the substitution to happen on a given line. But then... editi: given by what? If by a line number, say the tenth, then it's easy; you just have to enhance the above to:

perl -pi.bak -e '$.==10 and s/manulation/modification/' file.txt
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If it's something different, then you have to tell us.

monks
I have to use this in file manipulation like,

              open(FILE,"....") or die $!;
              while(<FILE>)
              {
                //Here Change part has to come

               }
              close FILE
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1)how to open a file like >+ or +<?.
2)how to modify with in this file in while loop
Thanks in advance

1)how to open a file like >+ or +<?.

From perldoc -f open:

You can put a '+' in front of the '>' or '<' to indicate that
you want both read and write access to the file; thus '+<' is
almost always preferred for read/write updates--the '+>' mode
would clobber the file first. You can't usually use either
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Curiously enough I wrote an explicit example yesterday in a thread with almost exactly the same subject as this one...