AFAIK, since the advent of PerlIO (which almost all perls are compiled/configured for these days), Perl chooses itself between block- or line-buffered, and you can only select unbuffered vs. the other two (with $|).
In earlier versions of Perl, when stdio (C runtime lib) was used by default, you could use setvbuf (via IO::Handle) to set buffering mode and buffer size.
These days, you usually get:
$ perl -MIO::Handle -e 'STDOUT->setvbuf($buf, _IOLBF, 2**16)'
IO::Handle::setvbuf not implemented on this architecture at -e line 1.
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