Lots of technologies have promised persistent Perl CGI on Windows -- PerlEx, Perl ISAPI, FastCGI -- but none of them actually work (per my extensive online research & testing).

HA! HA! HA!

• Perl as FastCGI : The Official Microsoft IIS Site
• Running Perl on IIS 7 : Wade Hilmo : The Official Microsoft IIS Site
• WebsitePanel - Installing and running Active Perl runtime as ISAPI on Microsoft IIS 7.0
• HOW TO: Configure and Test a PERL Script with IIS 4.0, 5.0, 5.1, and 6.0
• http://docs.activestate.com/activeperl/5.14/faq/Windows/ActivePerl-Winfaq6.html#microsoft_web_servers