Probably it matters. From ibidem:

«Perl Bindings...The RNA module to access RNAlib C-library functions from within Perl scripts»

I understand this like this: You don’t need to shell-out. You can do the stuff in pure Perl. If you fork or use threads is your design decision.

Update: See here

«The Crux of the Biscuit is the Apostrophe»

In reply to Re^5: Perl threads loss of performance with system call by karlgoethebier
in thread Perl threads loss of performance with system call by daniel85

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