Have you searched Makefile.PL for example for sybintl ? It seems to have only one occurrence. I would assume that this would be a proper place to make the change.
As to the need of modification, as Makefile.PL is a (Perl) program like many others, it is most likely that it simply doesn't support the detection and adaption to the bitness.
In reply to Re^5: DBD::Sybase make fails because of incompatible shared object(.so)
by Corion
in thread DBD::Sybase - 'make' fails because of incompatible shared object(.so)
by fire_blade
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