my $data =">DL;H1_ENSP00000194530_chr2_202024 CCCC---GCCTTCTCGCTGCCCAG
+C--CCCGGGGAGGGAGG*";

$data =~ s/[-*]|DL;//g;  # globaly, replace all "-" or "*" OR "DL;" wi
+th nothing
                         # ignores possibility "DL;" appears elsewhere
+ in data
                         # if that's an issue, you might want to do tw
+o substitutions
                         # $data =~ s/[-*]//g;  and $data =~ s/(>)DL;/
+$1/g;
                         # though that last is NOT tied to the beginni
+ng of the line
                         # which appears to be subject to brain_block 
+at the moment
print $data;

=head OUTPUT

perl dataclean.pl
>H1_ENSP00000194530_chr2_202024 CCCCGCCTTCTCGCTGCCCAGCCCCGGGGAGGGAGG

=cut
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