"ROSE" has got to be the weirdest line ending I've ever seen.

I took the liberty of cleaning up your code a bit.

• I fixed a bug where a single message could be considered two.
• I eliminated the select which needlessly served to empty the pipe.
• I replaced split since you have a record terminator rather than a record separator.

# Non blocking open
open (FH, "+<", $config->{'pipe'} ) || die "Unable to open $config->{'
+pipe'}";

my $buf = '';

# Loop forever.
while (1) {
    my $rv = sysread( FH, $buf, 2048, length($buf) );
    die("Error reading from pipe: $!\n") if !defined($rv);

    # 9/4/8 A request is C,DIR,1ROSE
    # Multiple requests can come through on one read ie C,FOO,1ROSEC,B
+AR,1ROSE
    while ($buf =~ s/(.*?ROSE)//s) {
       my $rec = $1;
       Log( { logfile => $log_file, text => "trace: START: $rec" }) if
+ TRACE;

        if ( $rec =~ /^RELOAD,/ ) {
            # Reread the config file
            Log({logfile=>$log_file, text=> qq{RELOAD: Reloading confi
+g}});
            load_config();
        }
        else {
            process_input( { data => $rec } );
        }
    }

} # while 1
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