Without knowing what "bunch of stuff" refers to it's impossible for me to know how to answer the question you've actually asked (and "no, I'm not clear what you mean by 'precompile'.")

So, with those caveats, an answer directed to another possible reading of your question...

If main.pl is producing a fundamentally static page (say something that says 'Welcome to whazit.com; our widgets are better than theirs. Buy now!' followed by links to additional content (such as pages targeted to the asserted advantages; price; and/or an E-commerce ordering page, you might consider using an index.html for the content you're now producing with main.pl, and reserve your hits on cgi-bin for dynamic pages.