There is no need for regex. It only takes a tr///d and a simple split():

while ( my $line = <DATA> ) {
  chomp $line;
  
  # backup of line, in case we need original version later
  my $line_copy = $line;

  # transliterate ',' into ';' remove '(', ')' and space(0x20)
  $line =~ tr/,() /;/d;

  # split at ';'
  my ( $first, $second, @rest ) = split /;/, $line;

  # do your work
}
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