Thanks...I read it just now :-) and tried this

#!/usr/local/bin/perl

use warnings;
use strict;
use LWP::Simple;
use HTML::TreeBuilder;
my @files = (["http://microrna.sanger.ac.uk/cgi-bin/targets/v5/detail_
+view.pl?transcript_id=ENST00000226253", "a.txt"],);  
for my $duplet (@files) {
    mirror($duplet->[0], $duplet->[1]);
};
open DATA, 'a.txt';
my $html = do{local $/;<DATA>};
my $p = HTML::TreeBuilder->new;
$p->parse_content($html); # parse_content if you have a string

my @tds = $p->look_down(_tag => q{td}); # get a list of all the td tag
+s
for my $td (@tds){
  my $bold = $td->look_down(_tag => q{b}); # look for a bold tag
  if ($bold){
    print $bold->as_text, qq{\n}; # if there is one print the text
  }
}
$p->delete; # when you've finished with it
[download]

so I have the last 2 question, to ask to monks....for today :-) : 1)shall I have to download the content of the web page...to work with filehandle DATA, this is the only way I find to make it works...2) the second question is: how to refine my script to make it prints only the data I need...thanks you all, you are essential for Perl community, and for my bioinformatics work....thanks

Your earlier post included something like:

my $url3="http://microrna.sanger.ac.uk/blah/blah";
my $content=get $url3;
[download]

This give you a string in $content that you can supply to $p->parse_content($content);.

I only used the special perl <DATA> file handle for the purposes of the example (so I could easily get a string of HTML). You won't need to do this as that is what LWP::Simple's get gives you.

You need to use the regex on the text, so something like this might do it (untested):

for my $td (@tds){
  my $bold = $td->look_down(_tag => q{b}); # look for a bold tag
  next unless $bold;
  my $txt = $bold->as_text;
  if ($txt=~ m/miR|let/){
    print $txt, qq{\n}; # if there is one print the text
  }
}
[download]

Hope that helps

if I understand correctly, I can do something like this, to parse without download the web page...

#!/usr/local/bin/perl

use warnings;
use strict;
use LWP::Simple;

my $url="http://microrna.sanger.ac.uk/cgi-bin/targets/v5/detail_view.p
+l?transcript_id=ENST00000226253";
my $content=get ($url);
use HTML::TreeBuilder;

my $p = HTML::TreeBuilder->new;
$p->parse_content($content); # parse_content if you have a string

my @tds = $p->look_down(_tag => q{td}); # get a list of all the td tag
+s
for my $td (@tds){
  my $bold = $td->look_down(_tag => q{b}); # look for a bold tag
  if ($bold){
    print $bold->as_text, qq{\n}; # if there is one print the text
  }
}
$p->delete; # when you've finished with it
[download]

but I don't understand why it doesn't give back me nothing, it seems as the content of the page has no bold string...that impossible...I see them and If I download the page like before and then do the parsing...it works...could you explain me why :-(... thanks too much