Also (and, I think, better)

I disagree. I think it's worse. I'll explain, but let's complete the code first.

The solution from the first post:

my %handlers = (
    ContentHandler => {
        '/' => sub { $self->{object}->Event() },
       #'/' => sub { $self->{object}->Event(@_) },
    },
);

my $cb = $handlers{ContentHandler};
... = $cb->();
#... = $cb->(...);
[download]

The solution you propose:

my %handlers = (
    ContentHandler => {
        '/' => $self->{object}->can('Event'),
    },
);

my $method = $handlers{ContentHandler};
... = $self->{object}->$method(...);
[download]

The problem is that you're getting the method of one object and you're calling it with a different object. Bad! If they aren't different object, then you have redundant code. Bad! The following would be a better version of your solution:

my %handlers = (
    ContentHandler => {
        '/' => 'Event',
    },
);

my $method = $handlers{ContentHandler};
... = $self->{object}->$method(...);
[download]

This revised solution and the one from the first post are equally good.